Azalanstat HCl

CAT: 0931-T70660-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-T70660-01Size:25 mg
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CAS Number
143484-82-6
Target
Others
Related Pathways
Others
Bioactivity
Azalanstat HCl is an anti-obesity drug acting as a lanosterol 14?-demethylase inhibitor. Azalanstat HCl has been shown to inhibit cholesterol synthesis in HepG2 cells, human fibroblasts, hamster hepatocytes and hamster liver, by inhibiting the cytochrome P450 enzyme lanosterol 14 alpha-demethylase. When administered orally to hamsters fed regular chow, RS-21607 (50 mg/kg/day) lowered serum cholesterol in a dose-dependent manner (ED50 = 62 mg/kg) in a period of 1 week. It preferentially lowered low density lipoprotein (LDL) cholesterol and apo B relative to high density lipoprotein (HDL) cholesterol and apo A-1.
Smiles
Cl.Nc1ccc(SC[C@@H]2CO[C@](CCc3ccc(Cl)cc3)(Cn3ccnc3)O2)cc1
Molecular Formula
C22H26Cl3N3O2S
Molecular Weight
502.879
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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