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Lanopepden camsylate

CAT: 0931-T70642-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T70642-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1441390-28-8
Target
Others
Related Pathways
Others
Bioactivity
Lanopepden, also known as GSK-1322322 or GSK-322, is a potent and selective peptide deformylase inhibitor with good in vitro activity against bacteria associated with community-acquired pneumonia and skin infections. GSK1322322 had bactericidal activity against S. pneumoniae, H. influenzae, S. pyogenes, and S. aureus, demonstrating a ≥ 3-log (10) decrease in the number of CFU/ml at 4x MIC within 24 h in 29 of the 33 strains tested. GSK1322322 represents a valuable alternative therapy for the treatment of infectious diseases caused by drug-resistant pathogens.
Smiles
CC1(C)C2CCC1(CS(O)(=O)=O)C(=O)C2.[H][C@]12COCCN1CCN(C2)c1nc(C)nc(NNC(=O)[C@H](CC2CCCC2)CN(O)C=O)c1F
Molecular Formula
C32H50FN7O8S
Molecular Weight
711.8514
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

N-[(2R)-3-[2-[6-[(9aS)-3,4,6,7,9,9a-hexahydro-1H-pyrazino[2,1-c][1,4]oxazin-8-yl]-5-fluoro-2-methylpyrimidin-4-yl]hydrazinyl]-2-(cyclopentylmethyl)-3-oxopropyl]-N-hydroxyformamide;(7,7-dimethyl-2-oxo-1-bicyclo[2.2.1]heptanyl)methanesulfonic acid
CAS Number1441390-28-8
PubChem CID159683027
IUPAC NameN-[(2R)-3-[2-[6-[(9aS)-3,4,6,7,9,9a-hexahydro-1H-pyrazino[2,1-c][1,4]oxazin-8-yl]-5-fluoro-2-methylpyrimidin-4-yl]hydrazinyl]-2-(cyclopentylmethyl)-3-oxopropyl]-N-hydroxyformamide;(7,7-dimethyl-2-oxo-1-bicyclo[2.2.1]heptanyl)methanesulfonic acid
Molecular FormulaC32H50FN7O8S
Molecular Weight711.8
Topological Polar Surface Area203
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count14
Rotatable Bond Count10
Heavy Atom Count49
Formal Charge0
Complexity1090
SMILES
CC1=NC(=C(C(=N1)N2CCN3CCOC[C@@H]3C2)F)NNC(=O)[C@H](CC4CCCC4)CN(C=O)O.CC1(C2CCC1(C(=O)C2)CS(=O)(=O)O)C
InChI
InChI=1S/C22H34FN7O4.C10H16O4S/c1-15-24-20(19(23)21(25-15)29-7-6-28-8-9-34-13-18(28)12-29)26-27-22(32)17(11-30(33)14-31)10-16-4-2-3-5-16;1-9(2)7-3-4-10(9,8(11)5-7)6-15(12,13)14/h14,16-18,33H,2-13H2,1H3,(H,27,32)(H,24,25,26);7H,3-6H2,1-2H3,(H,12,13,14)/t17-,18+;/m1./s1
InChIKey
MVLAZTDMRJUAQK-URBRKQAFSA-N
Chemical Structure
2D Structure
2D structure of N-[(2R)-3-[2-[6-[(9aS)-3,4,6,7,9,9a-hexahydro-1H-pyrazino[2,1-c][1,4]oxazin-8-yl]-5-fluoro-2-methylpyrimidin-4-yl]hydrazinyl]-2-(cyclopentylmethyl)-3-oxopropyl]-N-hydroxyformamide;(7,7-dimethyl-2-oxo-1-bicyclo[2.2.1]heptanyl)methanesulfonic acid
CAS: 1441390-28-8
CID: 159683027
Formula: C32H50FN7O8S
MW: 711.8
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight711.8
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count14
Rotatable Bond Count10
Exact Mass711.34256091
Monoisotopic Mass711.34256091
Topological Polar Surface Area203 Ų
Heavy Atom Count49
Formal Charge0
Complexity1090
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count2
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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