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CHF-6366

CAT: 0931-T70376-01Size: 100 mgDry Ice: NoHazardous: No
CAT#:0931-T70376-01Size:100 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1615208-41-7
Target
Others|||AChR|||Calcium Channel|||Adrenergic Receptor
Related Pathways
GPCR/G Protein|||Metabolism|||Neuroscience|||Others|||Membrane transporter/Ion channel
Bioactivity
CHF-6366 is a dual-action chemical compound acting as a potent M3 muscarinic antagonist and ?2-adrenergic receptors agonist, with respective pK i values of 10.4 and 11.4. Additionally, it exhibits weak calcium channel inhibitory properties (IC 50 ~50 ?M) and demonstrates the ability to inhibit bronchoconstriction in guinea pigs, making it a viable candidate for chronic obstructive pulmonary disease (COPD) research.
Smiles
[C@@H](CNCCCCOC(=O)C=1C=C(COC2=CC([C@@H](NC(O[C@@H]3C4CCN(C3)CC4)=O)C5=CC=CC=C5)=CC=C2)N(C)N1)(O)C6=C7C(=C(O)C=C6)NC(=O)C=C7
Molecular Formula
C42H48N6O8
Molecular Weight
764.87
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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