CHF-6366

• CAS Number :

  1615208-41-7

• Target :

  Others|||AChR|||Calcium Channel|||Adrenergic Receptor

• Related Pathways :

  GPCR/G Protein|||Metabolism|||Neuroscience|||Others|||Membrane transporter/Ion channel

• Bioactivity :

  CHF-6366 is a dual-action chemical compound acting as a potent M3 muscarinic antagonist and ?2-adrenergic receptors agonist, with respective pK i values of 10.4 and 11.4. Additionally, it exhibits weak calcium channel inhibitory properties (IC 50 ~50 ?M) and demonstrates the ability to inhibit bronchoconstriction in guinea pigs, making it a viable candidate for chronic obstructive pulmonary disease (COPD) research.

• Smiles :

  [C@@H](CNCCCCOC(=O)C=1C=C(COC2=CC([C@@H](NC(O[C@@H]3C4CCN(C3)CC4)=O)C5=CC=CC=C5)=CC=C2)N(C)N1)(O)C6=C7C(=C(O)C=C6)NC(=O)C=C7

• Molecular Formula :

  C42H48N6O8

• Molecular Weight :

  764.87

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C