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JTP-4819

CAT: 0931-T70365-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-T70365-01Size:25 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
162203-65-8
Target
Others|||Prolyl Endopeptidase (PREP)
Related Pathways
Proteases/Proteasome|||Others|||Metabolism
Bioactivity
JTP-4819 is a potent and selective prolyl endopeptidase (PEP) inhibitor with potential for treating Alzheimer's disease. At nanomolar concentrations, it inhibited the degradation of substance P, arginine-vasopressin, and thyrotropin-releasing hormone by PEP in supernatants of the rat cerebral cortex and hippocampus. Repeated administration of JTP-4819 reversed the aging-induced decrease in brain substance P-like and thyrotropin-releasing hormone-like immunoreactivity, suggesting it may improve the imbalance of peptidergic neuronal systems that develops with senescence by inhibiting PEP activity. Additionally, JTP-4819 increased acetylcholine release from the frontal cortex and hippocampus, regions closely associated with memory, in both young and aged rats.
Smiles
C(=O)([C@H]1N(C(NCC2=CC=CC=C2)=O)CCC1)N3[C@H](C(CO)=O)CCC3
Molecular Formula
C19H25N3O4
Molecular Weight
359.42
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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