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F-1394

CAT: 0931-T70356-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T70356-01Size:25 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
162490-89-3
Target
Acyltransferase, Others
Related Pathways
Others, Metabolism
Bioactivity
F-1394 is an acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor. F-1394 both prevents the formation of atherosclerosis and accelerates its regression without affecting the serum TC level, indicating that F-1394 acts directly on the arterial wall. F-1394 significantly reduced neointimal thickening and the extent of macrophages in lesions without affecting serum cholesterol levels. In vitro, F-1394 attenuated foam cell formation in mouse peritoneal macrophages.
Smiles
C(NCCC(O[C@@H]1[C@@H](NC(N(CCCCCCCCC)CC(C)(C)C)=O)CCCC1)=O)(=O)[C@H]2C(C)(C)COC(C)(C)O2
Molecular Formula
C33H61N3O6
Molecular Weight
595.85
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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