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PH11

CAT: 0931-T70352-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T70352-01Size:25 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1627843-95-1
Target
Others, FAK
Related Pathways
Tyrosine Kinase/Adaptors, Cytoskeletal Signaling, Angiogenesis, Others
Bioactivity
PH11 is a novel Focal Adhesion Kinase (FAK) inhibitor. PH11 restores TRAIL apoptotic pathway in PANC-1 cells through down-regulation of c-FLIP via inhibition of FAK and the phosphatidylinositol-3 kinase (PI3K) /AKT pathways. Tumor necrosis factor (TNF) -related apoptosis-inducing ligand (TRAIL) emerges as one of the most-promising experimental cancer therapeutic drugs and is currently being tested in clinical trials. However, both intrinsic and acquired resistance of human cancer cells to TRAIL-induced apoptosis poses a huge problem in establishing clinically efficient TRAIL therapies.
Smiles
N(C=1N2C(N=C(NC3=C(C(OC)=O)C=CC=C3)N1)=NC=C2)C4=CC(OC)=C(OC)C(OC)=C4
Molecular Formula
C22H22N6O5
Molecular Weight
450.45
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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