PH11

• Target :

  Others|||FAK

• Related Pathways :

  Tyrosine Kinase/Adaptors|||Cytoskeletal Signaling|||Angiogenesis|||Others

• Bioactivity :

  PH11 is a novel Focal Adhesion Kinase (FAK) inhibitor. PH11 restores TRAIL apoptotic pathway in PANC-1 cells through down-regulation of c-FLIP via inhibition of FAK and the phosphatidylinositol-3 kinase (PI3K) /AKT pathways. Tumor necrosis factor (TNF) -related apoptosis-inducing ligand (TRAIL) emerges as one of the most-promising experimental cancer therapeutic drugs and is currently being tested in clinical trials. However, both intrinsic and acquired resistance of human cancer cells to TRAIL-induced apoptosis poses a huge problem in establishing clinically efficient TRAIL therapies.

• Smiles :

  N(C=1N2C(N=C(NC3=C(C(OC)=O)C=CC=C3)N1)=NC=C2)C4=CC(OC)=C(OC)C(OC)=C4

• Molecular Formula :

  C22H22N6O5

• Molecular Weight :

  450.45

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  1627843-95-1