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BMS-186511

CAT: 0931-T70287-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T70287-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
167467-53-0
Target
Others, Transferase
Related Pathways
Others, Metabolism
Bioactivity
BMS-186511 is a Farnesyltransferase (FT) inhibitor with potential anticancer activity. BMS-186511 is a bisubstrate analogue inhibitor of FT, would inhibit the malignant growth properties of a cell line established from malignant schwannoma of an NF1 patient. Following treatment with BMS-186511 , ST88-14 cells became flat, nonrefractile, were contact-inhibited, and lost their ability to grow in soft agar. BMS-186511 was found to specifically inhibit FT, but not geranylgeranyltransferase I, a closely related enzyme. Thus, it is conceivable that FT inhibitors may ultimately become the first generation of drugs against the malignant phenotype in NF1 based on rational insights into the mechanism of action of neurofibromin.
Smiles
[C@H](C(N[C@@H](CCSC)C(OC)=O)=O)(NC([C@@H](NC(CCP(C/C=C(/CC/C=C(/CCC=C(C)C)\C)\C)(=O)O)=O)C(C)C)=O)[C@H](C)C
Molecular Formula
C34H60N3O7PS
Molecular Weight
685.89
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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