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Tofacitinib HCl

CAT: 0931-T70168-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T70168-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1803005-18-6
Target
Others
Related Pathways
Others
Bioactivity
Tofacitinib HCl, also known as tasocitinib, CP-690550, is a Janus kinase (JAK) inhibitor. Tofacitinib HCl modulates the signaling pathway at the point of JAKs, preventing the phosphorylation and activation of STATs. JAK enzymes transmit cytokine signaling through pairing of JAKs (e.g., JAK1/JAK3, JAK1/JAK2, JAK1/TyK2, JAK2/JAK2) . Tofacitinib HCl inhibited the in vitro activities of JAK1/JAK2, JAK1/JAK3, and JAK2/JAK2 combinations with IC50 of 406, 56, and 1377 nM, respectively.
Smiles
Cl.C[C@@H]1CCN(C[C@@H]1N(C)c1ncnc2[nH]ccc12)C(=O)CC#N
Molecular Formula
C16H21ClN6O
Molecular Weight
348.835
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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