Tofacitinib

• Target :

  Apoptosis|||ROCK|||JAK|||Src

• Related Pathways :

  Cell Cycle/Checkpoint|||JAK/STAT signaling|||Cytoskeletal Signaling|||Tyrosine Kinase/Adaptors|||Chromatin/Epigenetic|||Angiogenesis|||Stem Cells|||Apoptosis

• Purity :

  >99.99%

• Bioactivity :

  Tofacitinib (Tasocitinib) is a Janus kinase inhibitor that inhibits JAK3/2/1 (IC50=1/20/112 nM) and is orally active. Tofacitinib is used for the treatment of moderate to severe rheumatoid arthritis.

• Smiles :

  C[C@@H]1CCN(C[C@@H]1N(C)C1=C2C=CNC2=NC=N1)C(=O)CC#N

• Molecular Formula :

  C16H20N6O

• Molecular Weight :

  312.37

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  477600-75-2