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NG25 trihydrochloride

CAT: 0931-T69898-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T69898-01Size:25 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2108554-00-1
Target
Ras, MAPK, Kras, Others
Related Pathways
Others, MAPK
Bioactivity
NG25 trihydrochloride is a type II kinase inhibitor that inhibits MAP4K2 and TAK1. It also inhibits the Src family kinases Src and LYN and Abl family kinases as well as CSK, FER, and p38α. NG 25 prevents TNF-α-induced IKKα/β phosphorylation and IκB-α degradation in L929 cells. It inhibits secretion of IFN-α and IFN-β induced by CpG type B and CL097, respectively. NG 25 decreases cell viability of HCT116KRASWT, and to a greater degree of HCT116KRASG13D, colorectal cancer cells in a concentration-dependent manner. It also reduces tumor growth and increases the number of TUNEL-positive tumor cells in a CT26KRASG12D mouse orthotopic model of colorectal cancer.
Smiles
Cl.Cl.Cl.CCN1CCN(Cc2ccc(NC(=O)c3ccc(C)c(Oc4ccnc5[nH]ccc45)c3)cc2C(F)(F)F)CC1
Molecular Formula
C29H33Cl3F3N5O2
Molecular Weight
646.96
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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