MS-177

• Target:

  PROTACs|||Histone Methyltransferase|||Apoptosis

• Related Pathways:

  Apoptosis|||Chromatin/Epigenetic|||PROTAC

• Bioactivity:

  MS-177 is a PROTAC EZH2 degrader that promotes cholangiocarcinoma growth through the EZH2-mediated WNT7B/?-catenin pathway.MS-177 inhibits the growth of leukemia cells, induces apoptosis, and cell cycle arrest.MS-177 induces degradation of the classical EZH2-PRC2 and the non-classical EZH2-cMyc complexes and activates the immune-responsive genes in MM cells.

• Smiles:

  O=C(NCC=1C(=O)NC(=CC1C)C)C2=CC(=CC3=C2C=NN3C(C)C)C=4C=NC(=CC4)N5CCN(CCNC(=O)CCOCCNC6=CC=CC=7C(=O)N(C(=O)C67)C8C(=O)NC(=O)CC8)CC5

• Molecular Formula:

  C48H55N11O8

• Molecular Weight:

  914.02

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2225938-86-1