MS-177

• Target:

  PROTACs|||Histone Methyltransferase|||Apoptosis

• Related Pathways:

  Apoptosis|||Chromatin/Epigenetic|||PROTAC

• Bioactivity:

  MS-177 is a PROTAC EZH2 degrader that promotes cholangiocarcinoma growth through the EZH2-mediated WNT7B/?-catenin pathway.MS-177 inhibits the growth of leukemia cells, induces apoptosis, and cell cycle arrest.MS-177 induces degradation of the classical EZH2-PRC2 and the non-classical EZH2-cMyc complexes and activates the immune-responsive genes in MM cells.

• Smiles:

  O=C (NCC=1C (=O) NC (=CC1C) C) C2=CC (=CC3=C2C=NN3C (C) C) C=4C=NC (=CC4) N5CCN (CCNC (=O) CCOCCNC6=CC=CC=7C (=O) N (C (=O) C67) C8C (=O) NC (=O) CC8) CC5

• Molecular Formula:

  C48H55N11O8

• Molecular Weight:

  914.02

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2225938-86-1