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JS25

CAT: 0931-T69646-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T69646-01Size:25 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2411771-95-2
Target
BTK, Others
Related Pathways
Tyrosine Kinase/Adaptors, Others, Angiogenesis
Bioactivity
JS25 is a selective, covalent BTK inhibitor that deactivates BTK by chelating Tyr551, exhibiting an IC50 of 5.8 nM. It suppresses cancer cell proliferation, induces pronounced cell death, and enhances Burkitt's lymphoma murine xenograft model outcomes. Importantly, JS25 efficiently penetrates the blood-brain barrier.
Smiles
O=C1N(C2=C3C(C=C(C=C3)C4=CC=C(NS(C)(=O)=O)C=C4)=NC=C2C=C1)C5=CC(NC(C=C)=O)=CC(C)=C5
Molecular Formula
C29H24N4O4S
Molecular Weight
524.59
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
HY-151808-01JS25

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