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JS25

CAT: 0013-GTR19210371-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19210371-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
JS25 is a potent, covalent BTK inhibitor that selectively inactivates BTK via Tyr551 chelation with an IC50 of 5.8 nM. It demonstrates robust anti-proliferative and pro-apoptotic effects in vitro and significantly improves outcomes in Burkitt's lymphoma murine xenograft models, with the added benefit of efficient blood-brain barrier penetration.
CAS Number
2411771-95-2
Field of Research
Cardiovascular Research, Signal Transduction
Smiles
O=C1N (C2=C3C (C=C (C=C3) C4=CC=C (NS (C) (=O) =O) C=C4) =NC=C2C=C1) C5=CC (NC (C=C) =O) =CC (C) =C5
Molecular Formula
C29H24N4O4S
Molecular Weight
524.59
Storage Conditions
-20°C
Notes
For research use only.

Alternative Products

CatalogName
HY-151808-01JS25

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