BI-0474

• Target:

  Ras|||Raf|||Kras

• Related Pathways:

  MAPK|||GPCR/G Protein

• Purity:

  >99.99%

• Bioactivity:

  BI-0474 is a potent KRASG12C inhibitor that inhibits GDP-KRAS::SOS1 protein-protein interactions with an IC50 value of 7.0 nM.BI-0474 exhibits significant antiproliferative activity against NCI-H358 cells harboring the G12C mutation, and shows significant anti-tumor activity in a non-small cell lung cancer xenograft model. activity.BI-0474 can be used for cancer research.

• Smiles:

  C[C@]1(C2=C(SC(N)=C2C#N)CCC1)C3=NC(=NO3)C=4N=C(C=C(C4)N5CCN(C(C=C)=O)CC5)N6[C@@H](C)CN(C)CC6

• Molecular Formula:

  C30H37N9O2S

• Molecular Weight:

  587.74

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2750570-55-7