Products for Research Use Only
RegisterLogin

Dexamethasone sodium succinate

CAT: 0931-T69323-01Size: 100 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0931-T69323-01Size:100 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
CAS Number
3800-84-8
Target
Others
Related Pathways
Others
Bioactivity
Dexamethasone sodium succinate is the acetate salt form of dexamethasone, which is a synthetic glucocorticoid; it combines high anti-inflammatory effects with low mineralocorticoid activity. At high doses (e.g. 40 mg), it reduces the immune response. Dexamethasone acetate (NEOFORDEX®) is indicated in adults for the treatment of symptomatic multiple myeloma in combination with other medicinal products. Dexamethasone has been shown to induce multiple myeloma cell death (apoptosis) via a down-regulation of nuclear factor-κB activity and an activation of caspase-9 through second mitochondria-derived activator of caspase (Smac; an apoptosis promoting factor) release. Prolonged exposure was required to achieve maximum levels of apoptotic markers along with increased caspase-3 activation and DNA fragmentation. Dexamethasone also down-regulated anti apoptotic genes and increased IκB-alpha protein levels. Dexamethasone apoptotic activity is enhanced by the combination with thalidomide......
Smiles
C[C@@]12[C@](C[C@H]([C@]2(O)C(COC(CCC([O-])=O)=O)=O)C)([H])[C@@]3([H])[C@]([C@H](C1)O)([C@@]4(C(CC3)=CC(C=C4)=O)C)F.[Na+]
Molecular Formula
C26H32FNaO8
Molecular Weight
514.52
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

Dexamethasone sodium succinate

Dexamethasone Sodium Succinate is the sodium succinate salt form of dexamethasone, a synthetic adrenal corticosteroid and derivative of hydrocortisone, with potent anti-inflammatory properties. In addition to binding to specific nuclear steroid receptors, dexamethasone also interferes with NF-kB activation and apoptotic pathways. This agent lacks the salt-retaining properties of other related adrenal hormones.

CAS Number3800-84-8
PubChem CID90479300
IUPAC Namesodium 4-[2-[(8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethoxy]-4-oxobutanoate
Molecular FormulaC26H32FNaO8
Molecular Weight514.5
Topological Polar Surface Area141
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count9
Rotatable Bond Count7
Heavy Atom Count36
Formal Charge0
Complexity1040
SMILES
C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)COC(=O)CCC(=O)[O-])O)C)O)F)C.[Na+]
InChI
InChI=1S/C26H33FO8.Na/c1-14-10-18-17-5-4-15-11-16(28)8-9-23(15,2)25(17,27)19(29)12-24(18,3)26(14,34)20(30)13-35-22(33)7-6-21(31)32;/h8-9,11,14,17-19,29,34H,4-7,10,12-13H2,1-3H3,(H,31,32);/q;+1/p-1/t14-,17+,18+,19+,23+,24+,25+,26+;/m1./s1
InChIKey
VEMKNVZPCCPUIL-NJVDTJLMSA-M
Chemical Structure
2D Structure
2D structure of Dexamethasone sodium succinate
CAS: 3800-84-8
CID: 90479300
Formula: C26H32FNaO8
MW: 514.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight514.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count9
Rotatable Bond Count7
Exact Mass514.19789042
Monoisotopic Mass514.19789042
Topological Polar Surface Area141 Ų
Heavy Atom Count36
Formal Charge0
Complexity1040
Isotope Atom Count0
Defined Atom Stereocenter Count8
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

Related Products

CatalogName
T6465-01Dexamethasone Sodium Phosphate
T88564-01Dexamethasone metasulfobenzoate sodium
T0270L-01Hydrocortisone sodium succinate
T8258-01Chloramphenicol succinate sodium
TSW-00793-01Dexamethasone β-D-glucuronide sodium
T40971-01Dehydroandrographolide succinate potassium sodium salt
T1076-01Dexamethasone
T23984Dexamethasone phosphate
T27152-01Dexamethasone Beloxil
TMIJ-0162-01Dexamethasone-d4

Alternative Products

CatalogName
GTR19210587-01Dexamethasone sodium succinate
C11016-25mgSodium succinate
B1588-5000Dexamethasone Sodium Phosphate
FD171219-01Dexamethasone sodium metasulfobenzoate
TRC-D118963-50MGDexamethasone Sodium Sulfobenzoate
GTR19236481-01Dexamethasone metasulfobenzoate sodium

Popular Products