CEP-7055

CAT: 0931-T69288-01Size: 25 mgDry Ice: NoHazardous: No

1 / 1

CAT#:0931-T69288-01Size:25 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Quick Request Actions

CAS Number

402857-58-3

Target

Others, VEGFR

Related Pathways

Tyrosine Kinase/Adaptors, Others, Angiogenesis

Bioactivity

CEP-18770 is an orally bioavailable synthetic P2 threonine boronic acid inhibitor of the chymotrypsin-like activity of the proteasome, with potential antineoplastic activity. Proteasome inhibitor CEP 18770 represses the proteasomal degradation of a variety of proteins, including inhibitory kappaBalpha (IkappaBalpha), resulting in the cytoplasmic sequestration of the transcription factor NF-kappaB; inhibition of NF-kappaB nuclear translocation and transcriptional up-regulation of a variety of cell growth-promoting factors; and apoptotic cell death in susceptible tumor cell populations. In vitro studies indicate that this agent exhibits a favorable cytotoxicity profile toward normal human epithelial cells, bone marrow progenitors, and bone marrow-derived stromal cells relative to the proteasome inhibitor bortezomib. The intracellular protein IkappaBalpha functions as a primary inhibitor of the proinflammatory transcription factor NF-kappaB.

Smiles

C(CCOC(CN(C)C)=O)N1C=2C(=C3C(=C4C2CC=5C4=CC=CC5)C(=O)NC3)C=6C1=CC=C(COC(C)C)C6

Molecular Formula

C32H35N3O4

Molecular Weight

525.64

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Chemical Information

Cep 7055

CAS Number	402857-58-3
PubChem CID	9936664
IUPAC Name	3-[14-oxo-7-(propan-2-yloxymethyl)-3,13-diazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1(16),2(10),4(9),5,7,11(15),17,19,21-nonaen-3-yl]propyl 2-(dimethylamino)acetate
Molecular Formula	C32H35N3O4
Molecular Weight	525.6
XLogP	4.5
Topological Polar Surface Area	72.8
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	10
Heavy Atom Count	39
Formal Charge	0
Complexity	895

SMILES

CC(C)OCC1=CC2=C(C=C1)N(C3=C2C4=C(C5=C3CC6=CC=CC=C65)C(=O)NC4)CCCOC(=O)CN(C)C

InChI

InChI=1S/C32H35N3O4/c1-19(2)39-18-20-10-11-26-23(14-20)29-25-16-33-32(37)30(25)28-22-9-6-5-8-21(22)15-24(28)31(29)35(26)12-7-13-38-27(36)17-34(3)4/h5-6,8-11,14,19H,7,12-13,15-18H2,1-4H3,(H,33,37)

InChIKey

UHEBDUAFKQHUBV-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 402857-58-3

CID: 9936664

Formula: C32H35N3O4

MW: 525.6

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	525.6
XLogP3	4.5
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	10
Exact Mass	525.26275661
Monoisotopic Mass	525.26275661
Topological Polar Surface Area	72.8 Å²
Heavy Atom Count	39
Formal Charge	0
Complexity	895
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Related Products

Catalog	Name
T9901A-1645-01	CEP-37248
T68537-01	CEP-14513
T2612-01	CEP-28122
T26979-01	CEP-8983
T6122-01	CEP-33779
T23873-01	CEP-2563
T68539-01	CEP-11981
T202268-01	CEP-751
T2655-01	CEP-37440
T30795-01	CEP-1612

Alternative Products

Catalog	Name
MBS5811838	CEP-7055
8108/5	CEP
LBGF-0722-GF66	Bifidobacterium longum; 7055
C4025-25	CEP-28122
B3271-5	CEP-37440
BA8880-10	CEP-40783
A1413-5	CEP-32496
A4146-5.1	CEP-33779
HY-117909-01	CEP-40125
HY-16135-01	CEP-11981

CEP-7055

Chemical Information

Related Products

Alternative Products

Popular Products