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ABE171

CAT: 0931-T69262-03Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0931-T69262-03Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
426268-06-6
Target
Others
Related Pathways
Others
Bioactivity
ABE171, also known as NVP-ABE171, is a potent and novel phosphodiesterase 4 inhibitor with anti-inflammatory activities. NVP-ABE171 inhibited the activity of phosphodiesterase 4A, 4B, 4C, and 4D with respective IC (50) values of 602, 34, 1230, and 1.5 nM. In human cells, NVP-ABE171 inhibited the eosinophil and neutrophil oxidative burst, the release of cytokines by T cells, and the tumor necrosis factor-alpha release from monocytes, in the nanomolar range. NVP-ABE171 inhibited the airway neutrophil influx and activation with an ED (50) in the range of 3 mg/kg. NVP-ABE171 shows activity both in vitro on human inflammatory cells and in vivo in animal models of lung inflammation.
Smiles
C(O)(=O)C1=CC=C(C=2N=C(C3=C(C2)C=CC=N3)C4=CC=5C(C=C4)=NON5)C=C1
Molecular Formula
C21H12N4O3
Molecular Weight
368.35
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

Nvp abe171

inhibits phosphodiesterase 4; structure in first source

CAS Number426268-06-6
PubChem CID9799389
IUPAC Name4-[8-(2,1,3-benzoxadiazol-5-yl)-1,7-naphthyridin-6-yl]benzoic acid
Molecular FormulaC21H12N4O3
Molecular Weight368.3
XLogP3.2
Topological Polar Surface Area102
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count3
Heavy Atom Count28
Formal Charge0
Complexity568
SMILES
C1=CC2=CC(=NC(=C2N=C1)C3=CC4=NON=C4C=C3)C5=CC=C(C=C5)C(=O)O
InChI
InChI=1S/C21H12N4O3/c26-21(27)13-5-3-12(4-6-13)17-10-14-2-1-9-22-19(14)20(23-17)15-7-8-16-18(11-15)25-28-24-16/h1-11H,(H,26,27)
InChIKey
IALXIRPKVRUJQO-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Nvp abe171
CAS: 426268-06-6
CID: 9799389
Formula: C21H12N4O3
MW: 368.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight368.3
XLogP33.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count3
Exact Mass368.09094026
Monoisotopic Mass368.09094026
Topological Polar Surface Area102 Ų
Heavy Atom Count28
Formal Charge0
Complexity568
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
MBS5811812ABE171
HY-114052NVP-ABE171

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