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Xylocydine

CAT: 0931-T68875-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T68875-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
685901-63-7
Target
CDK, Others
Related Pathways
Cell Cycle/Checkpoint, Others
Bioactivity
Xylocydine is a novel Cdk inhibitor, which is an effective inducer of apoptosis in hepatocellular carcinoma cells in vitro and in vivo. Xylocydine also strongly inhibits the activity of Cdk7 and Cdk9, in vitro as well as in cell cultures, that is temporally associated with apoptotic cell death in xylocydine-induced HCC cells. Xylocydine can effectively suppress the growth of HCC xenografts in Balb/C-nude mice by preferentially inducing apoptosis in the xenografts, whereas the drug did not cause any apparent toxic effect on other tissues.Xylocydine is a good candidate for an anti-cancer drug for HCC therapy.
Smiles
BrC=1N(C=2C(C1C(N)=O)=C(N)N=CN2)[C@H]3O[C@@H](CO)[C@@H](O)[C@@H]3O
Molecular Formula
C12H14BrN5O5
Molecular Weight
388.17
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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