Abarelix acetate

• Target :

  Others|||GNRH Receptor

• Related Pathways :

  Others|||GPCR/G Protein

• Bioactivity :

  Abarelix acetate is a synthetic third generation gonadotropin-releasing hormone receptor (GnRHR) antagonist. It increases histamine release from rat peritoneal mast cells in vitro and from a human skin model ex vivo. In vivo, abarelix decreases plasma luteinizing hormone (LH) levels six hours post-treatment in castrated rats, with levels returning to baseline within 24 hours.3 Abarelix (2 mg/kg) also transiently decreases plasma testosterone levels in intact rats, with levels returning to baseline within seven days post-treatment. Formulations containing abarelix have previously been used in the treatment of advanced prostate cancer.

• Smiles :

  C(C)(O)=O.C([C@@H](NC([C@@H](NC([C@H](NC([C@H](CC1=CC=C(O)C=C1)N(C([C@@H](NC([C@@H](CC=2C=CC=NC2)NC([C@@H](CC3=CC=C(Cl)C=C3)NC([C@@H](CC4=CC5=C(C=C4)C=CC=C5)NC(C)=O)=O)=O)=O)CO)=O)C)=O)CC(N)=O)=O)CC(C)C)=O)CCCCNC(C)C)(=O)N6[C@H](C(N[C@@H](C(N)=O)C)=O)CCC6

• Molecular Formula :

  C72H95ClN14O14.xC2H4O2

• Molecular Weight :

  1476.14

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  785804-17-3