GPI-15427

• Target :

  PARP|||Others

• Related Pathways :

  Others|||DNA Damage/DNA Repair|||Chromatin/Epigenetic

• Bioactivity :

  GPI-15427 is a potent PARP-1 inhibitor capable of crossing the blood-brain barrier, which can significantly increased the antitumor activity of the methylating agent TMZ against malignant melanoma, glioblastoma multiforme, or lymphoma growing at the CNS site. GPI-15427 acts as a potent inhibitor of the enzyme, being capable of inhibiting the activity of purified PARP-1 at nanomolar concentrations. GPI-15427 induced significant sensitization to radiotherapy, representing a promising new treatment in the management of HNSCC.

• Smiles :

  O=C1C2=C3C(C=4C(OC3=CC=C2)=CC=C(CN5CCN(C)CC5)C4)=NN1

• Molecular Formula :

  C20H20N4O2

• Molecular Weight :

  348.4

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  805242-85-7