GPI-15427

CAT: 0931-MF-0143471-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0143471-01Size:25 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
CAS Number
805242-85-7
Target
PARP|||Others
Related Pathways
Others|||DNA Damage/DNA Repair|||Chromatin/Epigenetic
Bioactivity
GPI-15427 is a potent PARP-1 inhibitor capable of crossing the blood-brain barrier, which can significantly increased the antitumor activity of the methylating agent TMZ against malignant melanoma, glioblastoma multiforme, or lymphoma growing at the CNS site. GPI-15427 acts as a potent inhibitor of the enzyme, being capable of inhibiting the activity of purified PARP-1 at nanomolar concentrations. GPI-15427 induced significant sensitization to radiotherapy, representing a promising new treatment in the management of HNSCC.
Smiles
O=C1C2=C3C(C=4C(OC3=CC=C2)=CC=C(CN5CCN(C)CC5)C4)=NN1
Molecular Formula
C20H20N4O2
Molecular Weight
348.4
Shipping Conditions
Cool pack
Storage Temperature
-20°C

Related Products

CatalogName
MF-0094143-01GPI-1485
MF-0020268-01GPi 688
MF-0022451-01GPI-1046
MF-0075523-01Anti-GPI Antibody (9J172)
MF-0075522-01Anti-GPI Antibody (7B780)
MF-0075524-01Anti-GPI Polyclonal Antibody
MF-0075521-01Anti-GPI Antibody (6K139)
MF-0104573-01GPI Protein, Mouse, Recombinant (His)
MF-0103576-01GPI Protein, Human, Recombinant (His)
MF-0105055-01GPI Protein, Rat, Recombinant (His & Myc)

Alternative Products

CatalogName
HY-15048GPI 15427
MBS5811223GPI-15427
TR516173Hoxc9 Mouse shRNA Plasmid (Locus ID 15427)
SR407386Hoxc9 Mouse siRNA Oligo Duplex (Locus ID 15427)
enz-430GPI
TL516173VHoxc9 Mouse shRNA Lentiviral Particle (Locus ID 15427)
A23644-50UGGpi Antibody
BA1909-50GPI-1046
sc-398381GPI (A-5)
HY-105450GPI-3000

Popular Products