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WP-1034

CAT: 0931-T68536-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-T68536-01Size:25 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
857064-42-7
Target
Others
Related Pathways
Others
Bioactivity
WP-1034 is a novel Jak-Stat inhibitor, which is active against AML blasts. WP-1034 effectively inhibited proliferation of OCIM2 cells and fresh AML samples. WP-1034 caused cell cycle arrest of OCIM2 cells in sub-Go phase. WP-1034 induced apoptosis of OCIM2 cells and that induction of apoptosis involved cleavage of caspase 3 and the DNA repair enzyme poly (adenosine diphosphate [ADP]-ribose) polymerase (PARP) .
Smiles
C(=C(/C(N[C@H](C)C1=CC=CC=C1)=O)\C#N)\C2=CC=C(N(=O)=O)C=C2
Molecular Formula
C18H15N3O3
Molecular Weight
321.33
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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