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SNX-7081

CAT: 0931-T68393-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T68393-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
908111-22-8
Target
Others
Related Pathways
Others
Bioactivity
NX-7081 is a novel small molecule inhibitor of Hsp90, which blocks components of inflammation, including cytokine production, protein kinase activity, and angiogenic signaling. SNX-7081 showed strong binding affinity to Hsp90 and expected induction of Hsp70. NF-kappaB nuclear translocation was blocked by SNX-7081 at nanomolar concentrations, and cytokine production was potently inhibited. Growth factor activation of ERK and JNK signaling was significantly reduced by SNX-7081. NO production was also sharply inhibited. In animal models, SNX-4414 fully inhibited paw swelling and improved body weight.
Smiles
CC=1C2=C(N(C1)C3=CC(N[C@@H]4CC[C@@H](O)CC4)=C(C(N)=O)C=C3)CC(C)(C)CC2=O
Molecular Formula
C24H31N3O3
Molecular Weight
409.52
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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