SNX-7081

• Target :

  Others

• Related Pathways :

  Others

• Bioactivity :

  NX-7081 is a novel small molecule inhibitor of Hsp90, which blocks components of inflammation, including cytokine production, protein kinase activity, and angiogenic signaling. SNX-7081 showed strong binding affinity to Hsp90 and expected induction of Hsp70. NF-kappaB nuclear translocation was blocked by SNX-7081 at nanomolar concentrations, and cytokine production was potently inhibited. Growth factor activation of ERK and JNK signaling was significantly reduced by SNX-7081. NO production was also sharply inhibited. In animal models, SNX-4414 fully inhibited paw swelling and improved body weight.

• Smiles :

  CC=1C2=C(N(C1)C3=CC(N[C@@H]4CC[C@@H](O)CC4)=C(C(N)=O)C=C3)CC(C)(C)CC2=O

• Molecular Formula :

  C24H31N3O3

• Molecular Weight :

  409.52

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  908111-22-8