USP8-IN-3

• Target:

  DUB

• Related Pathways:

  Ubiquitination|||Cell Cycle/Checkpoint|||DNA Damage/DNA Repair

• Purity:

  0.9979

• Bioactivity:

  USP8-IN-3 is a potent inhibitor of the deubiquitinating enzymes USP7 and USP8, with IC50 of 4.0 ?M against USP8D. USP8-IN-3 inhibited the proliferation of GH3 and H1957 cells with GI50 values of 37.03 ?M and 6.01 ?M, respectively. USP8-IN-3 is a potential compound for the treatment of cancer and viral infections.

• Smiles:

  C(F)(F)(F)C1=NC(=CC=C1)N2CCC(NC(NC3=CC=C(N(=O)=O)C=C3)=S)CC2

• Molecular Formula:

  C18H18F3N5O2S

• Molecular Weight:

  425.43

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2477651-10-6