AT-533

• Target:

  VEGFR|||NF-?B|||Akt|||HSP|||ERK|||HIF/HIF Prolyl-Hydroxylase|||FAK|||HSV

• Related Pathways:

  PI3K/Akt/mTOR signaling|||Cytoskeletal Signaling|||Metabolism|||Microbiology/Virology|||Tyrosine Kinase/Adaptors|||NF-?B|||Angiogenesis|||MAPK|||Chromatin/Epigenetic

• Purity:

  0.9967

• Bioactivity:

  AT-533 is a potent inhibitor of Hsp90 and HSV. AT-533 blocks the HIF-1?/VEGF/VEGFR-2 signaling pathway, leading to suppress tumor growth and angiogenesis. AT-533 also inhibits the activation of the downstream pathways, including Erk1/2, FAK, Akt/mTOR/p70S6K, . AT-533 inhibits the cell migration, invasion, and the tube formation of human umbilical vein endothelial cells (HUVECs) .

• Smiles:

  Cc1nn(c2CC(C)(C)CC(=O)c12)-c1ccc(C(N)=O)c(N[C@H]2CC[C@H](O)CC2)c1

• Molecular Formula:

  C23H30N4O3

• Molecular Weight:

  410.51

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  908112-37-8