AT-533

CAT: 0931-T67836-01Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0931-T67836-01Size:1 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

908112-37-8

Target

VEGFR, NF-κB, Akt, HSP, ERK, HIF/HIF Prolyl-Hydroxylase, FAK, HSV

Related Pathways

PI3K/Akt/mTOR signaling, Cytoskeletal Signaling, Metabolism, Microbiology/Virology, Tyrosine Kinase/Adaptors, NF-κB, Angiogenesis, MAPK, Chromatin/Epigenetic

Purity

0.9967

Bioactivity

AT-533 is a potent inhibitor of Hsp90 and HSV. AT-533 blocks the HIF-1α/VEGF/VEGFR-2 signaling pathway, leading to suppress tumor growth and angiogenesis. AT-533 also inhibits the activation of the downstream pathways, including Erk1/2, FAK, Akt/mTOR/p70S6K, . AT-533 inhibits the cell migration, invasion, and the tube formation of human umbilical vein endothelial cells (HUVECs) .

Smiles

Cc1nn(c2CC(C)(C)CC(=O)c12)-c1ccc(C(N)=O)c(N[C@H]2CC[C@H](O)CC2)c1

Molecular Formula

C23H30N4O3

Molecular Weight

410.51

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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BA1998-10	AT-533
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A24155-50	AT-533 50mg
A24155-5	AT-533 5mg
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AT-533

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