D-GsMTx4 TFA

• Target:

  PI3K|||mTOR|||Akt|||Piezo Channel|||Calcium Channel|||TRP/TRPV Channel

• Related Pathways:

  Membrane transporter/Ion channel|||PI3K/Akt/mTOR signaling|||Metabolism|||Cytoskeletal Signaling

• Purity:

  0.9965

• Bioactivity:

  D-GsMTx4 TFA, a selective spider venom peptide, is a TRPC1/6 and Piezo2 inhibitor that inhibits cation-permeable mechanosensitive channels (MSCs) belonging to the Piezo and TRP channel families, blocks cation-selective stretch-activated channels (SACs), and attenuates lysophosphatidylcholine (LPC) -induced astrocyte toxicity and microglia reactivity. toxicity and microglia reactivity.D-GsMTx4 TFA prevented myocardial infarction in a mouse model of ischemia/reperfusion and can be used to characterize the role of excitatory MSCs in normal physiology and pathology.

• Smiles:

  [H]NCC(N[C@@H](CS)C(N[C@H](C(N[C@H](C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CC2=CNC3=C2C=CC=C3)C(N[C@@H](CC4=CNC5=C4C=CC=C5)C(N[C@H](C(N[C@@H](CS)C(N[C@H](C(N6CCC[C@H]6C(N[C@H](C(N[C@@H](CC(O)=O)C(N[C@@H](CC(O)=O)C(N[C@H](C(N[C@@H](CS)C(N[C@@H](CS)C(N[C@H](C(N7CCC[C@H]7C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CS)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC8=CC=CC=C8)C(N[C@H](C(N[C@H](C(N[C@@H](CS)C(N[C@H](C(N[C@@H](CC9=CC=CC=C9)C(N[C@H](C(N[C@@H](CC%10=CC=CC=C%10)C(O)=O)=O)CO)=O)=O)CC(N)=O)=O)=O)CC(C)C)=O)CCCCN)=O)=O)CC(C)C)=O)CCCCN)=O)CO)=O)=O)CCCCN)=O)CC(C)C)=O)CCCCN)=O)=O)CCCNC(N)=N)=O)=O)=O)CCCCN)=O)=O)=O)CC(N)=O)=O)=O)CC(N)=O)=O)=O)CCCCN)=O)=O)=O)=O)CCC(O)=O)=O)CC(C)C)=O)=O.OC(C(F)(F)F)=O

• Molecular Formula:

  C187H279F3N48O48S6

• Molecular Weight:

  4216.93

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C