KB-15

• Target :

  ROS|||Apoptosis|||PARP|||STAT

• Related Pathways :

  Apoptosis|||Chromatin/Epigenetic|||Immunology/Inflammation|||JAK/STAT signaling|||Stem Cells|||DNA Damage/DNA Repair

• Bioactivity :

  KB-15 is a STAT3 inhibitor exhibiting significant antiproliferative activity against AGS gastric cancer cells (IC50 = 0.29 ?M) and BGC-823 gastric cancer cells (IC50 = 0.65 ?M) . It exerts its antitumor effects by inhibiting STAT3 phosphorylation, downregulating HO-1 expression, and promoting intracellular reactive oxygen species (ROS) accumulation. Additionally, KB-15 induces G0/G1 phase cell cycle arrest and apoptosis while hindering colony formation and migration in gastric cancer cells. In the BGC-823 subcutaneous xenograft model, KB-15 demonstrates excellent antitumor efficacy.

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C