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KB-15

CAT: 0931-T212527-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-T212527-01Size:10 mg
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PRICE
AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
ROS|||Apoptosis|||PARP|||STAT
Related Pathways
Apoptosis|||Chromatin/Epigenetic|||Immunology/Inflammation|||JAK/STAT signaling|||Stem Cells|||DNA Damage/DNA Repair
Bioactivity
KB-15 is a STAT3 inhibitor exhibiting significant antiproliferative activity against AGS gastric cancer cells (IC50 = 0.29 ?M) and BGC-823 gastric cancer cells (IC50 = 0.65 ?M) . It exerts its antitumor effects by inhibiting STAT3 phosphorylation, downregulating HO-1 expression, and promoting intracellular reactive oxygen species (ROS) accumulation. Additionally, KB-15 induces G0/G1 phase cell cycle arrest and apoptosis while hindering colony formation and migration in gastric cancer cells. In the BGC-823 subcutaneous xenograft model, KB-15 demonstrates excellent antitumor efficacy.
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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