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Kv7.2/Kv7.3 activator-3

CAT: 0931-T212470-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T212470-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1361107-81-4
Target
Others, Potassium Channel
Related Pathways
Others, Membrane transporter/Ion channel
Bioactivity
Kv7.2/Kv7.3 activator-3 (GRT-X) is an orally active activator of Kv7.2/Kv7.3 channels and the TSPO. It activates Kv7.2/Kv7.3, Kv7.4, and Kv7.5 with EC50 values of 0.37, 2.06, and 0.75 μM, respectively, and binds to TSPO with Ki values of 0.07 μM (rat membrane) and 4.60 μM (human U-118 MG cells) . This compound protects motor neurons from degeneration caused by exposure to astrocyte-conditioned media from mice and humans with amyotrophic lateral sclerosis/frontotemporal dementia. Additionally, Kv7.2/Kv7.3 activator-3 stimulates axonal growth in dorsal root ganglia through TSPO and Kv7.2/3 activation and exhibits anticonvulsant effects in epilepsy models. It alleviates hyperalgesia in diabetic neuropathy patients, enhances the survival and regeneration of neurons after cervical neuropathy in rats, and accelerates the recovery of normal function in sensory and motor neurons.
Smiles
O=C(NCC=1C=CC=C(F)C1)C=2C(=O)N(C=3C=C(C=CC3C2C)C(F)(F)F)CCOC
Molecular Formula
C22H20F4N2O3
Molecular Weight
436.4
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

N-[(3-fluorophenyl)-methyl]-1-(2-methoxy-ethyl)-4-methyl-2-oxo-7-(trifluoromethyl)-1H-quinoline-3-carboxylic acid amide
CAS Number1361107-81-4
PubChem CID56847013
IUPAC NameN-[(3-fluorophenyl)methyl]-1-(2-methoxyethyl)-4-methyl-2-oxo-7-(trifluoromethyl)quinoline-3-carboxamide
Molecular FormulaC22H20F4N2O3
Molecular Weight436.4
XLogP3.8
Topological Polar Surface Area58.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count6
Heavy Atom Count31
Formal Charge0
Complexity709
SMILES
CC1=C(C(=O)N(C2=C1C=CC(=C2)C(F)(F)F)CCOC)C(=O)NCC3=CC(=CC=C3)F
InChI
InChI=1S/C22H20F4N2O3/c1-13-17-7-6-15(22(24,25)26)11-18(17)28(8-9-31-2)21(30)19(13)20(29)27-12-14-4-3-5-16(23)10-14/h3-7,10-11H,8-9,12H2,1-2H3,(H,27,29)
InChIKey
XPANITDISRRBCJ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N-[(3-fluorophenyl)-methyl]-1-(2-methoxy-ethyl)-4-methyl-2-oxo-7-(trifluoromethyl)-1H-quinoline-3-carboxylic acid amide
CAS: 1361107-81-4
CID: 56847013
Formula: C22H20F4N2O3
MW: 436.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight436.4
XLogP33.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count6
Exact Mass436.14100515
Monoisotopic Mass436.14100515
Topological Polar Surface Area58.6 Ų
Heavy Atom Count31
Formal Charge0
Complexity709
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
GTR19264660-01Kv7.2/Kv7.3 activator-3
GTR19257584-01Kv7.2/Kv7.3 activator-2
GTR19237824-01Kv7.2/Kv7.3 activator-1
GTR19274846-01Kv7.2/Kv7.3 modulator-3
HY-172585Kv7.2/Kv7.3 modulator-2
HY-180468Kv7 activator-2
GTR19258148-01Kv7.2/Kv7.3 modulator-1
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