SMI-10B13

• Target:

  Interleukin|||STAT

• Related Pathways:

  Immunology/Inflammation|||Stem Cells|||JAK/STAT signaling

• Bioactivity:

  SMI-10B13 is an inhibitor of oncostatin M (OSM) with a dissociation constant (KD) of 6.6 ?M. It effectively inhibits OSM-mediated STAT3 phosphorylation in T47D and MCF-7 cell lines, with IC50 values of 136 nM and 164 nM, respectively. SMI-10B13 demonstrates antitumor activity in a human breast cancer mouse model.

• Smiles:

  O=C (O) C=CC=1OC (C=2C=CC=3C=CNC3C2) =C (C1) C=4C=CC=5C=CNC5C4

• Molecular Formula:

  C23H16N2O3

• Molecular Weight:

  368.39

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2502294-68-8