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SMI-10B13

CAT: 0931-T212456-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T212456-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2502294-68-8
Target
Interleukin, STAT
Related Pathways
Immunology/Inflammation, Stem Cells, JAK/STAT signaling
Bioactivity
SMI-10B13 is an inhibitor of oncostatin M (OSM) with a dissociation constant (KD) of 6.6 μM. It effectively inhibits OSM-mediated STAT3 phosphorylation in T47D and MCF-7 cell lines, with IC50 values of 136 nM and 164 nM, respectively. SMI-10B13 demonstrates antitumor activity in a human breast cancer mouse model.
Smiles
O=C(O)C=CC=1OC(C=2C=CC=3C=CNC3C2)=C(C1)C=4C=CC=5C=CNC5C4
Molecular Formula
C23H16N2O3
Molecular Weight
368.39
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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