USP10-IN-4

• Target:

  MDM-2/p53|||Apoptosis|||CDK|||YAP|||DUB

• Related Pathways:

  Cell Cycle/Checkpoint|||Ubiquitination|||Apoptosis|||DNA Damage/DNA Repair|||Stem Cells

• Bioactivity:

  USP10-IN-4 is a potent inhibitor of ubiquitin-specific protease 10 (USP10), with an IC50 of 10.87 ?M and a Kd of 365 nM. It effectively inhibits USP10-mediated proteasomal degradation of downstream proteins YAP and p53, leading to the downregulation of CDK4 in the p53 signaling pathway. USP10-IN-4 promotes apoptosis in liver cancer cells (apoptosis) and inhibits the initiation and progression of liver cancer. It is applicable in the study of hepatocellular carcinoma (HCC) .

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C