USP10-IN-4

CAT: 0931-T212347-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0931-T212347-01Size:10 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Target

MDM-2/p53, Apoptosis, CDK, YAP, DUB

Related Pathways

Cell Cycle/Checkpoint, Ubiquitination, Apoptosis, DNA Damage/DNA Repair, Stem Cells

Bioactivity

USP10-IN-4 is a potent inhibitor of ubiquitin-specific protease 10 (USP10), with an IC50 of 10.87 μM and a Kd of 365 nM. It effectively inhibits USP10-mediated proteasomal degradation of downstream proteins YAP and p53, leading to the downregulation of CDK4 in the p53 signaling pathway. USP10-IN-4 promotes apoptosis in liver cancer cells (apoptosis) and inhibits the initiation and progression of liver cancer. It is applicable in the study of hepatocellular carcinoma (HCC) .

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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USP10-IN-4

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