STAT-3/c-Src-IN-1

• Target:

  Apoptosis|||STAT|||Src

• Related Pathways:

  Stem Cells|||Apoptosis|||Tyrosine Kinase/Adaptors|||JAK/STAT signaling|||Angiogenesis

• Bioactivity:

  STAT-3/c-Src-IN-1 (Compound 12d) is a dual inhibitor of STAT-3 (IC50=0.844 ?M) and c-Src (IC50=0.268 ?M) . It effectively disrupts tumor cell proliferation, migration, and angiogenesis pathways. This compound exhibits potent antiproliferative activity against melanoma (SK-MEL-2) and central nervous system cancer (SNB-75) cell lines, with GI50 values of -5.75 ?M and -5.63 ?M, respectively. It induces apoptosis through cell cycle arrest at the G0/G1 and G2/M phases. STAT-3/c-Src-IN-1 shows promise for research in melanoma and glioblastoma.

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C