STAT-3/c-Src-IN-1

CAT: 0931-MF-0119262-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0119262-01Size:10 mg
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Apoptosis|||STAT|||Src
Related Pathways
Stem Cells|||Apoptosis|||Tyrosine Kinase/Adaptors|||JAK/STAT signaling|||Angiogenesis
Bioactivity
STAT-3/c-Src-IN-1 (Compound 12d) is a dual inhibitor of STAT-3 (IC50=0.844 ?M) and c-Src (IC50=0.268 ?M) . It effectively disrupts tumor cell proliferation, migration, and angiogenesis pathways. This compound exhibits potent antiproliferative activity against melanoma (SK-MEL-2) and central nervous system cancer (SNB-75) cell lines, with GI50 values of -5.75 ?M and -5.63 ?M, respectively. It induces apoptosis through cell cycle arrest at the G0/G1 and G2/M phases. STAT-3/c-Src-IN-1 shows promise for research in melanoma and glioblastoma.
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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