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STAT-3/c-Src-IN-1

CAT: 0931-T212271-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T212271-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Apoptosis, STAT, Src
Related Pathways
Stem Cells, Apoptosis, Tyrosine Kinase/Adaptors, JAK/STAT signaling, Angiogenesis
Bioactivity
STAT-3/c-Src-IN-1 (Compound 12d) is a dual inhibitor of STAT-3 (IC50=0.844 μM) and c-Src (IC50=0.268 μM) . It effectively disrupts tumor cell proliferation, migration, and angiogenesis pathways. This compound exhibits potent antiproliferative activity against melanoma (SK-MEL-2) and central nervous system cancer (SNB-75) cell lines, with GI50 values of -5.75 μM and -5.63 μM, respectively. It induces apoptosis through cell cycle arrest at the G0/G1 and G2/M phases. STAT-3/c-Src-IN-1 shows promise for research in melanoma and glioblastoma.
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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