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KZR-261

CAT: 931-T211909-01Size: 10 mgDry Ice: NoHazardous: No
10 mgSelected
PRICE
AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2376747-46-3
Target
Others|||Caspase|||Apoptosis
Related Pathways
Others|||Proteases/Proteasome|||Apoptosis
Bioactivity
KZR-261 is a Sec61 inhibitor that directly binds to the Sec61 channel, effectively impeding the synthesis of certain Sec61 client proteins. It exhibits broad anti-tumor activity, particularly against colorectal, pancreatic, and prostate cancers, activating the endoplasmic reticulum stress response while showing minimal adverse effects on normal cells. KZR-261 significantly induces apoptosis in H929 cells and effectively suppresses tumor growth in various xenograft mouse models, demonstrating good tolerability.
Smiles
C[C@H]1N([C@H](C)CN(S(=O)(=O)N2C[C@@H](C)CN(S(=O)(=O)C3=CC=C(N(C)C)C=C3)CCCN(CC4CCCCC4)CCC2)C1)C5=CC(OC)=CC(F)=C5
Molecular Formula
C38H61FN6O5S2
Molecular Weight
765.06
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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