KZR-261

• Target:

  Others|||Caspase|||Apoptosis

• Related Pathways:

  Others|||Proteases/Proteasome|||Apoptosis

• Bioactivity:

  KZR-261 is a Sec61 inhibitor that directly binds to the Sec61 channel, effectively impeding the synthesis of certain Sec61 client proteins. It exhibits broad anti-tumor activity, particularly against colorectal, pancreatic, and prostate cancers, activating the endoplasmic reticulum stress response while showing minimal adverse effects on normal cells. KZR-261 significantly induces apoptosis in H929 cells and effectively suppresses tumor growth in various xenograft mouse models, demonstrating good tolerability.

• Smiles:

  C[C@H]1N ([C@H] (C) CN (S (=O) (=O) N2C[C@@H] (C) CN (S (=O) (=O) C3=CC=C (N (C) C) C=C3) CCCN (CC4CCCCC4) CCC2) C1) C5=CC (OC) =CC (F) =C5

• Molecular Formula:

  C38H61FN6O5S2

• Molecular Weight:

  765.06

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2376747-46-3