TBPH

CAT: 0931-T211712-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0931-T211712-01Size:10 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Target

Mitochondrial Metabolism, Interleukin, PERK, Cytochromes P450, HSP, Protease, LDLR, TNF

Related Pathways

Cytoskeletal Signaling, Apoptosis, Metabolism, Immunology/Inflammation, Proteases/Proteasome

Bioactivity

TBPH exacerbates liver steatosis, inflammation, and fibrosis in non-alcoholic steatohepatitis (NASH) mouse models. It induces phospholipid metabolism disorders, reducing cardiolipin (CL) and phosphatidylserine (PS) levels. TBPH impairs endoplasmic reticulum-mitochondria (ER-Mito) contact, leading to mitochondrial dysfunction. Additionally, TBPH causes lung injury through mitochondrial-derived ds-DNA-mediated inflammatory responses. TBPH is utilized to study the role of MFN2-mediated ER-Mito contact in lipid metabolism homeostasis.

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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TBPH

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