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Yoda2

CAT: 0931-T211683-02Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0931-T211683-02Size:50 mg
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CAS Number
3081450-95-2
Target
Piezo Channel, NO Synthase
Related Pathways
Membrane transporter/Ion channel, Immunology/Inflammation
Bioactivity
Yoda2 (KC289), the potassium salt of Yoda1, is an agonist of PIEZO1 with an EC50 of 150 nM. It induces Ca2+ elevation in HeLa cells and can cause concentration-dependent and NO-dependent relaxation in mouse portal vein (EC50= 1.2 μM) . Additionally, Yoda2 is capable of stimulating NOS3 and promoting NO production.
Smiles
O=C(C1=CC=C(C2=NN=C(SCC3=C(Cl)C=CC=C3Cl)S2)C=C1)[O-].[K+]
Molecular Formula
C16H9Cl2KN2O2S2
Molecular Weight
435.39
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

Yoda2 (KC289)
CAS Number3081450-95-2
PubChem CID170908031
IUPAC Namepotassium 4-[5-[(2,6-dichlorophenyl)methylsulfanyl]-1,3,4-thiadiazol-2-yl]benzoate
Molecular FormulaC16H9Cl2KN2O2S2
Molecular Weight435.4
Topological Polar Surface Area119
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count6
Rotatable Bond Count5
Heavy Atom Count25
Formal Charge0
Complexity434
SMILES
C1=CC(=C(C(=C1)Cl)CSC2=NN=C(S2)C3=CC=C(C=C3)C(=O)[O-])Cl.[K+]
InChI
InChI=1S/C16H10Cl2N2O2S2.K/c17-12-2-1-3-13(18)11(12)8-23-16-20-19-14(24-16)9-4-6-10(7-5-9)15(21)22;/h1-7H,8H2,(H,21,22);/q;+1/p-1
InChIKey
OQEIWUHZUPFUQU-UHFFFAOYSA-M
Chemical Structure
2D Structure
2D structure of Yoda2 (KC289)
CAS: 3081450-95-2
CID: 170908031
Formula: C16H9Cl2KN2O2S2
MW: 435.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight435.4
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count6
Rotatable Bond Count5
Exact Mass433.9119568
Monoisotopic Mass433.9119568
Topological Polar Surface Area119 Ų
Heavy Atom Count25
Formal Charge0
Complexity434
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

Related Products

CatalogName
T7506-01Yoda 1

Alternative Products

CatalogName
HY-175416-01Yoda2

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