PBD dimer-4

• Target :

  Others|||DNA Alkylator/Crosslinker

• Related Pathways :

  Others|||DNA Damage/DNA Repair

• Bioactivity :

  PBD dimer-4 (Compound 7) is a C1-substituted PBD dimer. This compound exhibits high DNA-binding affinity, effective DNA cross-linking ability, and potent cytotoxicity against MDA-MB-231 cells (IC50: 236 nM) . PBD dimer-4 serves as a payload in the ADC drug Loncastuximab tesirine, utilized for treating various cancer types.

• Smiles :

  O(CCCO[C@@H]1[C@@]2(N(CC1)C(=O)C=3C(N=C2)=CC(OC)=C(OC)C3)[H])[C@@H]4[C@@]5(N(C(=O)C=6C(N=C5)=CC(OC)=C(OC)C6)CC4)[H]

• Molecular Formula :

  C31H36N4O8

• Molecular Weight :

  592.64

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  1821339-88-1