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MI891

CAT: 0931-T211422-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T211422-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2530027-77-9
Target
Others, Cytochromes P450
Related Pathways
Others, Metabolism
Bioactivity
MI891 is a highly selective PXR antagonist (IC50= 3.76 μM, Kd= 1.7 μM) and inverse agonist (IC50= 6.1 μM) . It selectively disrupts the interaction between PXR and its coactivator SRC1. MI891 effectively inhibits Rifampicin-induced PXR activation and can be utilized in research on metabolic and other diseases.
Smiles
O=C(N)C1=CC(=CC=C1Cl)CN2N=NC(=C2)C3=C(N=C4C(F)=CC(F)=CN43)C=5C=CC(Cl)=CC5
Molecular Formula
C23H14Cl2F2N6O
Molecular Weight
499.3
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
GTR19263817-01MI891

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