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RN341

CAT: 0931-T211251-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T211251-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
LRRK2
Related Pathways
Autophagy
Bioactivity
RN341 is a LRRK2-specific type II kinase inhibitor (IC50 of 296 nM) . It prevents the phosphorylation of LRRK2 by stabilizing an open conformation, thereby avoiding S935 dephosphorylation. Additionally, RN341 rescues LRRK2-mediated kinesin motility blockage by preventing microtubule binding. This compound effectively inhibits both wild-type and G2019S LRRK2 at the cellular level, offering a novel avenue for Parkinson's disease research.
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
HY-174427RN341

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