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Topobexin

CAT: 0931-T211232-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T211232-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
3076446-44-8
Target
Topoisomerase
Related Pathways
DNA Damage/DNA Repair
Bioactivity
Topobexin (Topobexin 9) is a highly selective TOP2B inhibitor. It selectively inhibits TOP2B in vitro and stabilizes TOP2B on DNA. Topobexin offers significant protection to cardiomyocytes against DAU-induced damage. In rabbit models, Topobexin prevents anthracycline-induced cardiotoxicity and the decrease in left ventricular contractile function caused by DAU.
Smiles
O=C1OC2=C(C=CC(OCCN3CCN(C)CC3)=C2C(=O)N4C=5C=CC=CC5CCC4)C(=C1)CCC
Molecular Formula
C29H35N3O4
Molecular Weight
489.61
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
HY-174374-01Topobexin

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