Vasoactive intestinal peptide

• Target:

  Interleukin|||COX

• Related Pathways:

  Neuroscience|||Immunology/Inflammation

• Bioactivity:

  Vasoactive intestinal peptide is an agonist of VPAC1/VPAC2 receptors (G protein-coupled receptors) . In a model of Pseudomonas aeruginosa-induced keratitis, it reduces corneal perforation rates, decreases bacterial load, and inhibits excessive neutrophil infiltration. It enhances anti-inflammatory mediators such as IL-10 and TGF-? while suppressing pro-inflammatory factors like IL-1? and TNF-?, and upregulates lipid mediator-related enzymes (SOCS3, COX-2, ALOX12) to facilitate inflammation resolution. Vasoactive intestinal peptide shows promise for the research of ocular infectious diseases.

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  37221-79-7