DW34

CAT: 0931-T210782-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0931-T210782-01Size:10 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

2758171-54-7

Target

Necroptosis, Epigenetic Reader Domain

Related Pathways

Apoptosis, Chromatin/Epigenetic

Bioactivity

DW34 is an orally bioactive pan-BRD4-D1-biased inhibitor that also exhibits BRD4-D2 activity. It demonstrates a low nanomolar inhibitory effect comparable to I-BET151 (EC50 value of 0.16 μM), with an EC50 value of 0.14 μM. DW34 significantly alleviates lipopolysaccharide (LPS) -induced liver inflammation and acetaminophen (APAP) -induced toxicity by reducing chemokine expression and cell necrosis.

Smiles

N1=NN(C(C=2N=C(OC=3C=C(C=C(C3)C)C)C=CC2)=C1C)C4CCN(CCN(C)C)CC4

Molecular Formula

C25H34N6O

Molecular Weight

434.58

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Chemical Information

2-(4-{5-[6-(3,5-dimethylphenoxy)pyridin-2-yl]-4-methyl-1H-1,2,3-triazol-1-yl}piperidin-1-yl)-N,N-dimethylethan-1-amine

CAS Number	2758171-54-7
PubChem CID	156022514
IUPAC Name	2-[4-[5-[6-(3,5-dimethylphenoxy)-2-pyridinyl]-4-methyltriazol-1-yl]piperidin-1-yl]-N,N-dimethylethanamine
Molecular Formula	C25H34N6O
Molecular Weight	434.6
XLogP	3.8
Topological Polar Surface Area	59.3
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	7
Heavy Atom Count	32
Formal Charge	0
Complexity	559

SMILES

CC1=CC(=CC(=C1)OC2=CC=CC(=N2)C3=C(N=NN3C4CCN(CC4)CCN(C)C)C)C

InChI

InChI=1S/C25H34N6O/c1-18-15-19(2)17-22(16-18)32-24-8-6-7-23(26-24)25-20(3)27-28-31(25)21-9-11-30(12-10-21)14-13-29(4)5/h6-8,15-17,21H,9-14H2,1-5H3

InChIKey

PIKWYDHWUKSWAQ-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 2758171-54-7

CID: 156022514

Formula: C25H34N6O

MW: 434.6

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	434.6
XLogP3	3.8
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	7
Exact Mass	434.27940973
Monoisotopic Mass	434.27940973
Topological Polar Surface Area	59.3 Å²
Heavy Atom Count	32
Formal Charge	0
Complexity	559
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Alternative Products

Catalog	Name
GTR19263293-01	DW34

DW34

Chemical Information

Alternative Products

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