WEE1-IN-12

• Target:

  Wee1

• Related Pathways:

  Cell Cycle/Checkpoint

• Bioactivity:

  WEE1-IN-12 (Compound 87) is a Wee1 kinase inhibitor with an IC50 of 2.0 nM. It inhibits the proliferation of HT29 cells (IC50: 1.07 ?M) and shows enhanced efficacy when combined with Gemcitabine (IC50: 0.34 ?M) . WEE1-IN-12 is applicable in the study of tumors such as colon cancer.

• Smiles:

  O=C(NC=1C(Cl)=CC=CC1Cl)C2=CN=C(N=C2OC3CC3)NC=4C=NN(C4)C5CCN(CCCNC6=CC=CC=7C(=O)N(C(=O)C67)C8C(=O)NC(=O)CC8)CC5

• Molecular Formula:

  C38H38Cl2N10O6

• Molecular Weight:

  801.68

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  3069940-37-7