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FXIIa-IN-5

CAT: 0931-T210261-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T210261-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
3047411-80-0
Target
Thrombin
Related Pathways
Proteases/Proteasome
Bioactivity
FXIIa-IN-5 (Compound 4J) is an orally effective selective inhibitor of factor XIIa (FXIIa), with an IC50 of 21 nM. It inhibits the intrinsic coagulation pathway and demonstrates anti-inflammatory and antithrombotic activities in a Carrageenan-induced thrombosis model in mice. FXIIa-IN-5 exhibits moderate pharmacokinetic properties and mild toxicity at a dosage of 100 mg/kg.
Smiles
O=C(C1=CC=C(C=2C=CC=CC12)N3CCN(CCC3)C(C)C)N4N=C(N=C4N)C=5N=CC=CC5
Molecular Formula
C26H29N7O
Molecular Weight
455.55
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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