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2-MeSADP

CAT: 0931-T210054-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T210054-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
34983-48-7
Target
P2Y Receptor
Related Pathways
Neuroscience, GPCR/G Protein
Bioactivity
2-MeSADP (2-Methylthioadenosine diphosphate; 2-Methylthio-ADP) is a potent agonist of purinergic (P2Y) receptors, displaying EC50 values of 19 nM for human P2Y13, 6.2 nM for mouse P2Y13, and 5 nM for human P2Y12. It also has pEC50 values of 8.29 for human P2Y1 and 5.75 for rat P2Y6. 2-MeSADP induces platelet aggregation and morphological changes, while inhibiting the accumulation of cyclic adenosine monophosphate in platelets in the presence of prostaglandin E1.
Smiles
O[C@H]1[C@H](N2C=3C(N=C2)=C(N)N=C(SC)N3)O[C@H](COP(OP(=O)(O)O)(=O)O)[C@H]1O
Molecular Formula
C11H17N5O10P2S
Molecular Weight
473.29
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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