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I1421

CAT: 0931-T209907-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T209907-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
CFTR
Related Pathways
Membrane transporter/Ion channel
Bioactivity
I1421 is an activator of the cystic fibrosis transmembrane conductance regulator (CFTR), with an EC50 of 64 nM for WTCFTR currents. It also allosterically activates various CF-causing mutants, demonstrating good in vivo efficacy with an oral bioavailability of 60% in mice and a corresponding half-life of 75 minutes. I1421 works synergistically with Elexacaftor to enhance CFTR currents.
Molecular Formula
C18H18FN3O3
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
HY-158991-01I1421

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