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I1421

CAT: 0804-HY-158991-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-158991-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
I1421 is an activator of the cystic fibrosis transmembrane conductance regulator (CFTR) with an EC50 of 64 nM for WT CFTR currents. I1421 also allosterically activates multiple mutants causing cystic fibrosis (CF) with good in vivo potency, with an oral bioavailability of 60% in mice corresponding to a half-life of 75 min. I1421 synergizes with Elexacaftor to enhance CFTR currents[1].
UNSPSC
12352005
Target
CFTR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/i1421.html
Purity
99.15
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(N1N=C(N)C2=C1C=C(CO)C=C2)[C@@H](C)COC3=CC=C(F)C=C3
Molecular Formula
C18H18FN3O3
Molecular Weight
343.35
References & Citations
[1]Liu F, et al. Structure-based discovery of CFTR potentiators and inhibitors. Cell. 2024 May 23:S0092-8674 (24) 00472-0.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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CatalogName
T209907-01I1421

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