QC-182

CAT: 0931-T209145-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0931-T209145-01Size:10 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

3032646-96-8

Target

PROTACs, Histone Acetyltransferase

Related Pathways

PROTAC, Chromatin/Epigenetic

Bioactivity

QC-182 is a potent p300/CBP PROTAC degrader. It reduces p300 protein levels in SK-HEP-1 cells with a DC50 of 93 nM. QC-182 effectively inhibits cell growth in SK-HEP-1 and JHH7 cell lines, with IC50 values of 0.733 μM and 0.477 μM, respectively. QC-182 is applicable for hepatocellular carcinoma (HCC) research.

Smiles

O=C1N([C@H](C=2N(C=3C(N2)=CC(=CC3)C=4C(C)=NOC4C)C5CCN(CC5)C6CN(C6)C=7C=C8C(=CC7)C(=O)N(C8=O)C9C(=O)NC(=O)CC9)CCC1)C%10=CC(F)=C(F)C=C%10

Molecular Formula

C44H42F2N8O6

Molecular Weight

816.85

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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