QC-182

• Target:

  PROTACs|||Histone Acetyltransferase

• Related Pathways:

  PROTAC|||Chromatin/Epigenetic

• Bioactivity:

  QC-182 is a potent p300/CBP PROTAC degrader. It reduces p300 protein levels in SK-HEP-1 cells with a DC50 of 93 nM. QC-182 effectively inhibits cell growth in SK-HEP-1 and JHH7 cell lines, with IC50 values of 0.733 ?M and 0.477 ?M, respectively. QC-182 is applicable for hepatocellular carcinoma (HCC) research.

• Smiles:

  O=C1N([C@H](C=2N(C=3C(N2)=CC(=CC3)C=4C(C)=NOC4C)C5CCN(CC5)C6CN(C6)C=7C=C8C(=CC7)C(=O)N(C8=O)C9C(=O)NC(=O)CC9)CCC1)C%10=CC(F)=C(F)C=C%10

• Molecular Formula:

  C44H42F2N8O6

• Molecular Weight:

  816.85

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  3032646-96-8