ATC-324

• Target:

  Androgen Receptor

• Related Pathways:

  Endocrinology/Hormones

• Bioactivity:

  ATC-324 is a potent autophagy-targeting chimera (AUTOTAC) degrader of the androgen receptor (AR) with a DC50 of 2.05 µM. It induces autophagic-lysosomal degradation of AR, decreases nuclear AR and AR-V7 activity, and exhibits cytotoxic effects on AR-positive prostate cancer cells, making it useful for prostate cancer research.

• Smiles:

  S=C1N(C(=O)C(C)(C)N1C2=CC(F)=C(C(NCCOCCOCCOCCOCCNC[C@H](COC3=CC(OCC4=CC=C(F)C=C4)=C(OCC5=CC=C(F)C=C5)C=C3)O)=O)C=C2)C6=CC(C(F)(F)F)=C(C#N)C=C6

• Molecular Formula:

  C53H55F6N5O10S

• Molecular Weight:

  1068.09

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2925060-81-5