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TRF1-TIN2 interaction-IN-1

CAT: 0931-T207708-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T207708-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Telomerase
Related Pathways
DNA Damage/DNA Repair
Bioactivity
TRF1-TIN2 interaction-IN-1 (Compound 40) is an inhibitor of the TRF1-TIN2 interaction. It binds to the TRFH domain of TRF1 (KD= 29 μM) and competitively inhibits the binding of the TIN2 peptide (IC50= 67 μM) . By occupying a hotspot at the TRF1-TIN2 interface, TRF1-TIN2 interaction-IN-1 disrupts the interaction between TRF1 and TIN2. This compound can remove TRF1 from the shelterin complex, making it useful for research on shelterin-related cancers.
Smiles
OS(C1=CC=C(OCC2=CC(OC)=CC(OC)=C2)C3=C1C=CC=C3)(=O)=O
Molecular Formula
C19H18O6S
Molecular Weight
374.41
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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