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HQY1428

CAT: 0931-T207664-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T207664-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
DNA/RNA Synthesis, Apoptosis, CDK
Related Pathways
Apoptosis, DNA Damage/DNA Repair, Cell Cycle/Checkpoint
Bioactivity
HQY1428 is an orally active CDK12 inhibitor. It impedes DNA replication, causing cell cycle arrest at the G2/M phase in SKOV3 cells, and induces DNA double-strand breaks as well as apoptosis. In the SKOV3 xenograft mouse model, HQY1428 demonstrates antitumor activity. Additionally, when combined with the HER2 inhibitor Lapatinib in the NCI-N87 xenograft mouse model, HQY1428 produces a synergistic therapeutic effect.
Molecular Formula
C25H28ClFN6O3S
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
HY-172970-01HQY1428

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