CW-2

CAT: 0931-T207351-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-T207351-01Size:10 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
PARP|||PROTACs|||DNA/RNA Synthesis
Related Pathways
Cell Cycle/Checkpoint|||DNA Damage/DNA Repair|||Chromatin/Epigenetic|||PROTAC
Bioactivity
CW-2 is a PARP1 PROTAC degrader known for its potent antiproliferative effects against MDA-MB-231 cells (IC50 = 0.72 ?M) and cisplatin-resistant cells (A549/CDDP: IC50 = 3.52 ?M) . It exhibits synergistic antitumor activity and enhanced membrane permeability. CW-2 exerts its antitumor effects by inducing DNA damage, disrupting DNA repair, and triggering mitochondrial-dependent apoptosis (apoptosis) .
Molecular Formula
C43H42Cl2FN11O10Pt
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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