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CW-2

CAT: 0931-T207351-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T207351-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Target
PARP, PROTACs, DNA/RNA Synthesis
Related Pathways
Cell Cycle/Checkpoint, DNA Damage/DNA Repair, Chromatin/Epigenetic, PROTAC
Bioactivity
CW-2 is a PARP1 PROTAC degrader known for its potent antiproliferative effects against MDA-MB-231 cells (IC50 = 0.72 μM) and cisplatin-resistant cells (A549/CDDP: IC50 = 3.52 μM) . It exhibits synergistic antitumor activity and enhanced membrane permeability. CW-2 exerts its antitumor effects by inducing DNA damage, disrupting DNA repair, and triggering mitochondrial-dependent apoptosis (apoptosis) .
Molecular Formula
C43H42Cl2FN11O10Pt
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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