CW-2

• Target :

  PARP|||PROTACs|||DNA/RNA Synthesis

• Related Pathways :

  Cell Cycle/Checkpoint|||DNA Damage/DNA Repair|||Chromatin/Epigenetic|||PROTAC

• Bioactivity :

  CW-2 is a PARP1 PROTAC degrader known for its potent antiproliferative effects against MDA-MB-231 cells (IC50 = 0.72 ?M) and cisplatin-resistant cells (A549/CDDP: IC50 = 3.52 ?M) . It exhibits synergistic antitumor activity and enhanced membrane permeability. CW-2 exerts its antitumor effects by inducing DNA damage, disrupting DNA repair, and triggering mitochondrial-dependent apoptosis (apoptosis) .

• Molecular Formula :

  C43H42Cl2FN11O10Pt

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C