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HDAC11-IN-3

CAT: 0931-T207278-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T207278-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2989934-63-4
Target
HDAC, Apoptosis, Ferroptosis
Related Pathways
DNA Damage/DNA Repair, Chromatin/Epigenetic, Apoptosis
Bioactivity
HDAC11-IN-3 (Compound A9) is a selective inhibitor of HDAC11, exhibiting an IC50 value of 4.1 nM. It demonstrates inhibitory effects on U937 and OCI-AML2 acute myeloid leukemia (AML) cell lines with an IC50 of 10 μM. This compound shows significant anti-AML activity by inducing apoptosis, cell cycle arrest, and differentiation. HDAC11-IN-3 upregulates the iron transport proteins transferrin (TF) and transferrin receptor (TFRC), and activates the p62-Keap1-Nrf2-HMOX1 pathway, which collectively increases intracellular iron levels and induces ferroptosis in AML cells. HDAC11-IN-3 can be utilized for AML research either alone or in combination with Cytarabine.
Smiles
O=C(NO)C=1C=CC=C2NC(C#CC3=CC=CC(=C3)C(F)(F)F)=CC21
Molecular Formula
C18H11F3N2O2
Molecular Weight
344.29
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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